RESVERATROL INTAKE DURING PREGNANCY AND LACTATION RE-PROGRAMS ADIPOSITY AND AMELIORATES LEPTIN RESISTANCE IN MALE PROGENY INDUCED BY MATERNAL HIGH-FAT/HIGH SUCROSE PLUS POSTNATAL HIGH-FAT/HIGH SUCROSE DIETS VIA FAT METABOLISM REGULATION

Abstract Background Maternal obesity is an emerging problem in the modern world.Growing evidence suggests that intrauterine high-fat (HF) exposure may predispose progeny to subsequent metabolic challenges.Progeny born to mothers who ate an HF diet also tends to eat an HF diet when growing and aggravate metabolic issues.Thus, the generational transm

Abstract Background The ubiquitous LysM motif recognizes peptidoglycan, chitooligosaccharides (chitin) and, presumably, other structurally-related oligosaccharides.LysM-containing proteins were first shown to be involved in bacterial cell wall degradation and, more recently, were implicated in perceiving chitin (one of the established pathogen-asso

Deubiquitinating enzymes (DUBs) are proteases that control the post-translational modification of proteins by ubiquitin Cardigan and in turn regulate diverse cellular pathways.Despite a growing understanding of DUB biology at the structural and molecular level, little is known about the physiological importance of most DUBs.Here, we systematically

A 10-year-old male miniature dachshund dog was referred to our hospi tal for cough and dyspnea.Two-dimensional echocardiography revealed pulmonary hypertension with an echo-free circle structure adjacent to the dorsal side of the Zero Pore Pad left atrium.The estimated systolic and mean pul monary arterial pressures were 50.4 and 36 mm Hg, respecti